R.N. McLaughlin, F.J. Poelwijk, A. Raman, W.S. Gosal, and R. Ranganathan. The Spatial Architecture of Protein Function and Adaptation. (2012) Nature, 138: 138-142. PDF, SI, DATA


K.A. Reynolds, W.P. Russ, M. Socolich, and R. Ranganathan. Evolution-based Design of Proteins. (2012) Methods in Enzymology, in press.


L. Ma and R. Ranganathan. Quantifying the Rhythm of KaiB-C Interactions for In Vitro Cyanobacterial Clock. (2012) PLoS One 7(8): e42581. PDF, SI


K.A. Reynolds, R.N. McLaughlin. R. Ranganathan.  Hotspots for Allosteric Regulation on Protein Surfaces.  (2011) Cell, 147: 1564-1575.  PDF, SI


B.Levine and R. Ranganathan. Snapshot of the Network.  (2010) Nature, 466: 38-40. PDF


R. Smock., J.F. Swain, W.P. Russ, R. Ranganathan, and L.M. Gierasch.  An Interdomain Sector Mediating Allostery in Hsp70 Molecular Chaperones. (2010) Molecular Systems Biology, 6: Article Number 414. PDF, SI


Halabi, N.*, Rivoire, O.*, S. Leibler, and R. Ranganathan. Protein Sectors: Evolutionary Units of Three-Dimensional Structure. (2009) Cell, 138: 774-786. PDF, SI   *co-first authors


Lee, J.*, Natarajan, M.*, V.C. Nashine, M. Socolich, T. Vo, W.P. Russ, S.J. Benkovic, and R. Ranganathan. Surface Sites for Engineering Allosteric Control in Proteins. (2008) Science, 322: 438-42. PDF, SI    *co-first authors


Pumir, A., J. Graves, R. Ranganathan, and B.I. Shraiman. (2008) Systems analysis of the single photon response in invertebrate photoreceptors. PNAS, 105: 10354-9. PDF, SI,


Mishra, PM, M. Wall, M. Socolich, J. Graves, ZF Wang, and R. Ranganathan (2007). Dynamic scaffolding in a G Protein coupled signaling system. Cell, 131:80-92 . PDF, SI, NV (Nature), NV (Nature Chemical Biology), Preview (Cell)


Laidlaw J, Gelfand Y, Ng KW, Garner HR, Ranganathan R, Benson G, Fondon JW 3rd. (2007) Elevated basal slippage mutation rates among the Canidae. J Hered., 98:452-60. PDF


Ranganathan, R. (2007). Signaling across the cell membrane. Science, 318: 1253-4. PDF


Ferguson, A.D., C.A. Amezcua, N.M. Halabi, Y. Chelliah, M.K. Rosen, R. Ranganathan, J. Deisenhofer (2007). Signal Transduction Pathway of TonB-dependent Transporters. PNAS, 104: 513-518. PDF


Poole, AM and R. Ranganathan (2006). Knowledge-based potentials in protein design. Current Opinion in Structural Biology, 16: 508-513. PDF


Natarajan, M, P.C. Sternweis, Alliance for Cellular Signaling Laboratories, and R. Ranganathan (2006). A Global Analysis of Cross-talk in a Mammalian Cellular Signaling Network. Nature Cell Biology, 8: 571-580. PDF


Socolich, M.*, S.W. Lockless*, H.L. Lee, K. Gardner, and R. Ranganathan (2005). Evolutionary Information for Specifying a Protein Fold. Nature, 437: 512-518., PDF, SI, NV (Nature), Preview (Cell)   *co-first authors


Russ, W., D.M. Lowery, P. Mishra, M.B. Yaffe, and R. Ranganathan (2005). Natural-like Function in Artificial WW Domains. Nature, 437:579-583. PDF, SI, NV (Nature), Preview (Cell)


Shulman, A.I., C. Larson, D.J. Mangelsdorf, R. Ranganathan (2004). Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers. Cell, 116: 417-429. PDF, Preview (Cell)


Ranganathan, R. (2003). A Matter of Life or Death. Science, 299: 1679-1680. PDF


Hatley, M.E., S.W. Lockless, S.K. Gibson, A.G. Gilman, and R. Ranganathan (2003). Allosteric Determinants of the Guanine Nucleotide Binding Proteins. PNAS, 100(24): 14445-14450. PDF


Jain, R.K., and R. Ranganathan (2003). Local Complexity of Amino-acid Interactions in a Protein Core. PNAS, 101(1): 111-116. PDF


Suel, G., S. W. Lockless, M. A. Wall, R. Ranganathan (2003). Evolutionarily Conserved Networks of Residues Mediate Allosteric Communication in Proteins. Nature Structural Biology, 10(1): 59-69. PDF


Russ, W. and R. Ranganathan (2002). Knowledge-based Potential Functions in Protein Design. Current Opinions in Structural Biology 12(4):447-452. PDF


Wall, M.A., M. Socolich, and R. Ranganathan (2000). The Structural Basis for Red Fluorescence in dsRED, a Tetrameric Green Fluorescent Protein Homolog. Nature Structural Biology, 7: 1133-1138. PDF


Kiselev, A., M. Socolich, J. Vinos, R.W. Hardy, C.S. Zuker, and R. Ranganathan (2000). A Molecular Pathway for Light-Dependent Photoreceptor Apoptosis in Drosophila. Neuron, 28: 139-152. PDF


Zuker, C.S. and R. Ranganathan (1999). Signal Transduction: The Path to Specificity. Science 283: 650-651.


Lockless, S.W. and R. Ranganathan (1999). Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families. Science 286: 295-299. PDF


Ranganathan, R. and E.M. Ross (1997). PDZ Domain Proteins: Scaffolds for Signaling Complexes. Current Biology 7: R770-R773.